Table 5 Univariate and multiple Cox regression overall survival analyses of PD-1 of TILs percentages in peritoneal metastases.

From: PD-1 and PD-L1 expression on TILs in peritoneal metastases compared to ovarian tumor tissues and its associations with clinical outcome

 

Overall survival

 

Univariate

Multiple

 

HR [CI95%]

P-value

HR [CI95%]

P-value

PD-1 TILs

(≥ 40% vs. < 40%)

0.52 [0.29–0.93]

0.028

0.40 [0.22–0.75]

0.004

Age (decades)

1.50 [1.15–1.97]

0.003

1.64 [1.22–2.19]

 < 0.001

Histology (HGSOC > Other)

2.62 [1.03–6.67]

0.043

n.i

 

Figo (IV > III > II > I)

3.77 [2.03–7.00]

 < 0.001

4.21 [2.18–8.14]

 < 0.001

Residual tumor mass (R1 > R0)

1.69 [0.91–3.15]

0.096

2.35 [1.18–4.67]

0.015

  1. Combined hazard ratios and p-values for the dichotomized PD-1 expression in TILs in univariate Cox-regressions (left) or multiple Cox-regressions, corrected for age, FIGO stage, and residual tumor mass (right). HR, Hazard Ratio; CI95%, 95% Confidence Interval; OS, overall survival; n.i., not included; according selection by the backward selection method minimizing the Akaike Information Criterion (AIC).
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