Table 6 Univariate and multiple Cox regression overall survival analyses of PD-L1 of TILs percentages in peritoneal metastases.

From: PD-1 and PD-L1 expression on TILs in peritoneal metastases compared to ovarian tumor tissues and its associations with clinical outcome

 

Overall survival

 

Univariate

Multiple

 

HR [CI95%]

P-value

HR [CI95%]

P-value

PD-L1 TILs

(≥ 15% vs. < 15%)

3.79 [1.56–9.23]

0.003

3.00 [1.05–8.72]

0.041

Age (decades)

1.46 [1.12–1.91]

0.005

1.67 [1.24–2.24]

 < 0.001

Histology (HGSOC > Other)

2.79 [1.00–7.83]

0.051

n.i

 

Figo (IV > III > II > I)

3.61 [1.95–6.65]

 < 0.001

3.07 [1.56–6.03]

0.001

Residual tumor mass (R1 > R0)

1.66 [0.90–3.08]

0.106

1.61 [0.83–3.11]

0.160

  1. Combined hazard ratios and p-values for the dichotomized PD-L1 expression in TILs in univariate Cox-regressions (left) or multiple Cox-regressions, corrected for age, FIGO stage, and residual tumor mass (right). HR, Hazard Ratio; CI95%, 95% Confidence Interval; OS, overall survival; n.i. = not included; according selection by the backward selection method minimizing the Akaike Information Criterion (AIC).
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