Figure 5
From: Metformin ameliorates the severity of experimental Alport syndrome
Transcriptome analysis reveals the comprehensive effects of metformin in glomeruli of Col4a5 G5X Alport syndrome mice. (a) Venn diagram shows the number of fluctuated genes in three comparisons (WT vs. Alport vehicle, Alport vehicle vs. Alport metformin, Alport vehicle vs Alport losartan). (b–d) Pathway analysis of fluctuated genes in the different treatment groups, as indicated. Red and blue bars represent the number of upregulated and downregulated genes, respectively. Pathways are displayed in ascending order of P value (P < 0.05). †: Common pathways between Alport vehicle vs Alport losartan + metformin group.
