Figure 2 | Scientific Reports

Figure 2

From: Structure based analysis of KATP channel with a DEND syndrome mutation in murine skeletal muscle

Figure 2

Cytosolic Ca2+ release in Kir6.2/R50P-expressing myotubes. (a–d) Representative changes of cytosolic Ca2+ ([Ca2+]i) images applying buffer (a) and 10 mM ACh (b–d) to non-transfected (b), Kir6.2/WT-expressing (c) and Kir6.2/R50P-expressing myotubes (d). (e) Mean firing frequency (± SEM) before and after 10 mM ACh stimulation at 5 min (N = 6–12). Multiple groups were compared by an ordinary one-way ANOVA test, followed by Tukey’s test (**p < 0.01; ****p < 0.001). The figures were analyzed and created with GraphPad Prism software (GraphPad Prism 8.2.1; https://www.graphpad.com/scientific-software/prism/).

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