Figure 4 | Scientific Reports

Figure 4

From: Structure based analysis of KATP channel with a DEND syndrome mutation in murine skeletal muscle

Figure 4

Comparison between before and after molecular dynamics simulation in R50P mutant. Before simulation, four ATP molecules were accommodated in the cavity (a), whereas after 500 ns, each adenosine moiety in the ATP is exposed to the solvent (b). The ATP molecule is weakly bound to the channel with three residues Lys39, Arg54, Lys185. The simulation was calculated by gromacs v2020.1 software (https://doi.org/10.5281/zenodo.3562512) and the figure was drawn in PyMol (http://pymol.sourceforge.net/).

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