Figure 6 | Scientific Reports

Figure 6

From: Astaxanthin protects against early acute kidney injury in severely burned rats by inactivating the TLR4/MyD88/NF-κB axis and upregulating heme oxygenase-1

Figure 6

Astaxanthin attenuates burn-induced inflammation through regulating TLR4 /MyD88/NF-κB pathway. (a) Representative bands of western blot are shown after introduction of LPS, TAK242 and PDTC. LPS reversed the effect of high-dose ATX on expression of TLR4, MyD88 and downstream phosphorylated activation of IKKα/β, Iκ, BαNF-κB, while both TAK242 and PDTC could help to enhance the effect of ATX; (b) The inhibition of ATX on release of selected inflammatory mediators could be abolished by LPS, and enhanceb by using TAK242 or PDTC. n = 6 for each group. The results are expressed as the mean ± SD. *p < 0.05, **p < 0.01, v.s. ATX 20 mg/kg; #p < 0.05, ##p < 0.01.

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