Figure 4 | Scientific Reports

Figure 4

From: Comparative in silico genome analysis of Clostridium perfringens unravels stable phylogroups with different genome characteristics and pathogenic potential

Figure 4

Accessory genome clustering and pangenome accumulation in 206 Clostridium perfringens strains. (A) Heat maps from similarity matrices calculated based on the distribution pattern of accessory genes (left) and the average nucleotide identity of the whole genome (right) in the 206 strains with phylogroups highlighted. Heat maps were generated using ComplexHeatmap 91 in R 87 and edited in Adobe Photoshop CS5 (www.adobe.com/photoshop). (B) Accumulation curves for the pangenome produced using vegan 86 in R 87 for the species (n = 206 strains, 14,942 genes) and the phylogroups I (n = 31 strains, 4,665 genes), II (n = 32 strains, 5,608 genes) and III (n = 135 strains, 12,713 genes). (C) Multidimensional scaling plot of the pangenome showing clustering of strains based on the pattern of presence and absence of accessory genes, with phylogroups highlighted and colour coded as calculated using the R function cmdscale () (goodness of fit = 0.3321971, X-axis eigenvalue = 0.2004366, and Y-axis eigenvalue = 0.1317606).

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