Table 1 Clinicopathological characteristics of patients with pancreatic cancer that underwent neoadjuvant therapy, showing the coincidence or discrepancy between macroscopy and histology.

From: Adequate tissue sampling for the assessment of pathological tumor regression in pancreatic cancer

Ā 

Total

Coincidence

Discrepancy

Number of patients, n (%)

137

101 (74)

36 (26)

Age, y

Mean, range

69, 49–87

70, 49–87

66, 49–84

 ≄ 70, n (%)

64 (47)

53 (39)

11 (8)

Sex, male, n (%)

86 (63)

67 (49)

19 (14)

Preoperative treatment, n (%)

CRT

85

68 (79)

17 (21*)

CT

52

33 (65)

19 (35)

Vascular invasion, n (%)

Positive

18

14 (78)

4 (22)

Negative

119

87 (73)

32 (27)

Perineural invasion, n (%)

Positive

109

82 (75)

27 (25)

Negative

28

19 (68)

9 (32)

Resection margin negative, n (%)

119 (87)

90 (66)

29 (21)

Stage (UICC 8th), n (%)

0

2

2 (100)

0 (0)

IA

7

4 (57)

3 (43)

IB

12

9 (75)

3 (25)

IIA

48

37 (77)

11 (23)

IIB

51

35 (69)

16 (31)

III

14

13 (93)

1 (7)

IV

3

1 (33)

2 (67)

Cancer size, mean ± S.D., mm

30.0 ± 15.9

28.9 ± 15.9

32.9 ± 15.9

Cancer location, n (%)

Head

93

66 (71)

27 (29)

Body/Tail

44

35 (80)

9 (20)

Pathological differentiation, n (%)

Well

70

52 (74)

18 (26)

Moderately

50

35 (70)

15 (30)

Poorly

12

9 (75)

3 (25)

Unclassified

5

5 (100)

0 (0)

Evans, n (%)

I, IIa

131

98 (75)

33 (25)

IIb, III, IV

6

3 (50)

3 (50)

JPS, n (%)

1

126

95 (75)

31 (25)

2–4

11

6 (55)

5 (45)

CAP, n (%)

0–2

15

14 (93)

1 (7*)

3

122

87 (71)

35 (29)

ART, n (%)

0–3

55

43 (78)

12 (22)

4

82

58 (71)

24 (29)

Necrosis, n (%)

Low, ~ 19%

70

58 (83)

12 (17*)

High, 20% ~

67

43 (64)

24 (36)

T/S ratio, n (%)

Low, ~ 39%

95

71 (75)

24 (25)

High, 40% ~

42

30 (71)

12 (29)

  1. CRT, chemoradiation; CT chemotherapy.; UICC, Union for International Cancer Control; T/S ratio, tumor stroma ratio.
  2. *P < 0.05 versus the coincidence group.
  3. Evans, JPS, CAP and ART scores were determined by all slides.