Figure 4
CFD simulated shear rates and shear rate gradients in eccentric (A–D) and concentric (E–H) stenoses geometry under various contraction angles. (A and E) The streamlines of blood flow in the eccentric stenosis and concentric stenosis microfluidic channel for α = 60° (top) and 30° (bottom) respectively. The representative streamline of a platelet trajectory was colored by shear rate values. (B and F) Peak shear rate γmax slightly changes correlated to the contraction angle for both eccentric and concentric stenoses geometries. Note that the eccentric stenosis upstream shear rate is higher than that of the concentric stenosis channel. The shear rate γ (C and G) and shear rate gradient γ′ (D and H) distribution is plotted along a sample streamline 1 µm above stenosis apex spanning the shear acceleration (x = −100 to 0 µm) and deceleration (x = 0–100 µm) zones. Note that the shear rates in the post-stenosis zone remain unchanged with respect to α, while the upstream of the pre-stenosis area displays faster acceleration.
