Table 5 Selected baseline variables in the LCA.
Class 1 | Class 2 | Class 3 | Class 4 | Class 5 | Class 6 | Class 7 | Class 8 | p | |
|---|---|---|---|---|---|---|---|---|---|
Nosocomial sterile sepsis | Sepsis with lactic acidosis | Community-acquired sterile | Abdominal pathogen detected | Nosocomial pathogen detected | Gram-positive bacteria | Immuno-suppressed sepsis | Urinary tract infection sepsis | ||
n = 20 | n = 37 | n = 130 | n = 56 | n = 34 | n = 112 | n = 20 | n = 60 | ||
Gender, female | 10 (10) | 15 (41) | 54 (42) | 26 (46) | 12 (35) | 47 (42) | 5 (25) | 30 (50) | 0.59 |
Bacteremia | 0 (0) | 34 (92) | 0 (0) | 28 (50) | 22 (65) | 86 (77) | 20 (100) | 58 (97) | < 0.01 |
Pathogen-detected | 0 (0) | 37 (100) | 5 (4) | 56 (100) | 34 (100) | 112 (100) | 20 (100) | 60 (100) | < 0.01 |
Foci of infection | |||||||||
Respiratory tract | 0 (0) | 4 (11) | 56 (43) | 8 (14) | 0 (0) | 45 (40) | 0 (0) | 2 (3) | < 0.01 |
Urinary tract | 0 (0) | 4 (11) | 4 (3) | 3 (5) | 3 (9) | 0 (0) | 0 (0) | 50 (83) | < 0.01 |
Abdominal | 0 (0) | 14 (38) | 49 (38) | 34 (61) | 0 (0) | 0 (0) | 0 (0) | 4 (7) | < 0.01 |
Postoperative | 20 (100) | 0 (0) | 0 (0) | 0 (0) | 28 (82) | 0 (0) | 0 (0) | 0 (0) | < 0.01 |
Skin & soft tissue | 0 (0) | 0 (0) | 2 (2) | 8 (14) | 0 (0) | 27 (24) | 1 (5) | 0 (0) | < 0.01 |
Nosocomial | 20 (100) | 3 (8) | 12 (9) | 2 (4) | 34 (100) | 0 (0) | 1 (5) | 0 (0) | < 0.01 |
Preceding antibiotics | 12 (60) | 9 (24) | 65 (50) | 25 (10) | 10 (29) | 23 (21) | 19 (95) | 4 (7) | < 0.01 |
Immuno-suppression | 2 (10) | 11 (30) | 33 (25) | 18 (32) | 5 (15) | 13 (12) | 17 (85) | 4 (7) | < 0.01 |
Organ dysfunction | |||||||||
Respiratory | 15 (73) | 37 (100) | 128 (98) | 51 (92) | 34 (100) | 101 (90) | 18 (90) | 54 (89) | 0.01 |
Coagulopathy | 1 (5) | 26 (70) | 36 (28) | 3 (5) | 6 (18) | 43 (38) | 19 (95) | 31 (53) | < 0.01 |
Liver | 2 (10) | 22 (59) | 16 (12) | 3 (5) | 3 (9) | 13 (12) | 5 (25) | 8 (13) | < 0.01 |
Cardiovascular | 16 (80) | 35 (96) | 81 (62) | 31 (55) | 13 (38) | 78 (69) | 11 (55) | 40 (60) | 0.02 |
CNS | 6 (30) | 22 (59) | 40 (31) | 13 (10) | 0 (0) | 44 (39) | 0 (0) | 15 (2) | < 0.01 |
Acidosis | 7 (35) | 35 (95) | 64 (49) | 21 (38) | 14 (41) | 66 (59) | 2 (10) | 12 (20) | < 0.01 |
Lactate < 1.7 | 9 (45) | 0 (0) | 32 (25) | 11 (20) | 7 (21) | 39 (35) | 6 (30) | 8 (13) | < 0.01 |
Lactate 1.8–3 | 5 (25) | 1 (3) | 40 (31) | 14 (25) | 9 (27) | 27 (24) | 24 (27) | 6 (30) | 0.09 |
Lactate 3.1–5.1 | 3 (15) | 4 (11) | 35 (27) | 19 (34) | 7 (21) | 20 (18) | 5 (25) | 21 (35) | 0.04 |
Lactate > 5.1 | 3 (15) | 32 (87) | 23 (18) | 12 (21) | 11 (32) | 26 (23) | 3 (15) | 15 (25) | < 0.01 |
Fever | 8 (40) | 4 (11) | 36 (28) | 10 (18) | 10 (29) | 41 (37) | 7 (35) | 14 (23) | 0.04 |
Hypothermia | 1 (5) | 12 (32) | 20 (15) | 5 (9) | 2 (6) | 10 (9) | 1 (5) | 5 (8) | < 0.01 |
S.aureus | 0 (0) | 1 (3) | 1 (1) | 0 (0) | 4 (12) | 24 (21) | 3 (15) | 0 (0) | < 0.01 |
Enterobacterales | 0 (0) | 15 (41) | 1 (1) | 10 (18) | 8 (24) | 3 (3) | 6 (30) | 55 (92) | < 0.01 |
Streptococci | 0 (0) | 0 (0) | 0 (0) | 2 (4) | 3 (9) | 77 (69) | 2 (10) | 0 (0) | < 0.01 |
Candida | 0 (0) | 1 (3) | 0 (0) | 0 (0) | 3 (9) | 0 (0) | 2 (10) | 0 (0) | < 0.01 |
Others | 0 (0) | 20 (54) | 2 (2) | 44 (79) | 16 (47) | 8 (7) | 7 (35) | 5 n | < 0.01 |
