Table 4 Statistical summary of the in situ hybridization.

From: Genome-wide transcriptome study in skin biopsies reveals an association of E2F4 with cadasil and cognitive impairment

  

Cases median (Q1–Q3)

Controls median (Q1–Q3)

p-value

EC

% Positive E2F4

(6 cases, 7 controls)

33% (31–33)

31% (29–35)

0.95

% Cells with dots (7 cases, 6 controls)

32% (31–33)

31% (29–33)

0.53

% Celss with clusters (6 cases, 8 controls)

7% (6–8)

6% (5–9)

0.66

VSMC

% Positive E2F4

(8 cases, 8 controls)

28% (27–30)

26% (24–30)

0.57

% Cells with dots (8 cases, 8 controls)

29% (27–31)

26% (21–29)

0.44

% Celss with clusters (7 cases, 8 controls)

30% (26–31)

26% (21–29)

0.12

  1. For endothelial cells and VSMC positive cells, there are: (1) Proportion of positive cells with E2F4, (2) Proportion of cells with E2F4 dots, and (3) Proportion of cells with E2F4 clusters.
  2. Samples with values below quartile 1 minus 1.5 times the interquartile range, or above quartile 3 plus 1.5 times the interquartile range, were considered outliers for that analysis and therefore removed.
  3. EC endothelial cells, VSMC vascular smooth muscle cells.
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