Table 4 Sex specific effects of risk factors on memory, and risk factor-by-wave interaction effects on memory decline (60 s cohort).

Genetic

APOE e4 (−/−)

Ref.

Ref.

APOE e4 (−/+)

− 0.12

− 0.34, 0.10

0.28

− 0.19

− 0.45, 0.06

0.14

APOE e4 (+/+)

− 1.07

− 1.77, − 0.36

 < 0.01

− 0.07

− 0.77,0.68

0.85

Demographic

Finance problem

− 0.41

− 0.72, − 0.11

0.01

− 0.14

− 0.47, 0.18

0.40

Interaction (wave × finance prob)

− 0.02

− 0.65, 0.61

0.94

− 0.01

− 0.59, 0.57

0.91

Lifestyle

Alcohol abstention

− 0.11

− 0.42, 0.30

0.74

− 0.46

− 0.76, − 0.17

 < 0.01

 Interaction (wave × alcohol abst)

− 0.12

− 0.58, 0.34

0.60

0.29

− 0.14, 0.72

0.18

Moderate physical activity

0.29

0.05, 0.53

0.02

0.33

0.06, 0.60

0.02

 Interaction (wave × mod activity)

− 0.11

− 0.47, 0.25

0.55

0.00

− 0.39, 0.40

0.98

Vigorous physical activity

0.36

0.05, 0.67

0.02

0.16

− 0.27, 0.60

0.47

 Interaction (wave × vig activity)

− 0.22

− 0.68, 0.25

0.36

− 0.09

− 0.871, 0.53

0.79

Cognitive engagement

0.36

0.05, 0.67

0.02

0.33

0.05, 0.62

0.02

 Interaction (wave × cog engage)

− 0.07

− 0.48, 0.34

0.74

− 0.06

− 0.46, 0.34

0.77

Schuster-social support score

0.02

0.00, 0.03

0.02

0.01

− 0.01, 0.02

0.48

 Interaction (wave × social support)

0.00

− 0.02, 0.02

0.90

0.00

− 0.02, 0.03

0.88

Medical

Hypertension

0.06

− 0.16, 0.28

0.61

− 0.31

− 0.54, − 0.08

0.01

 Interaction (wave × hypertension)

− 0.02

− 0.31, 0.34

0.92

0.27

− 0.09, 0.63

0.14

Stoke

0.04

− 0.37, 0.44

0.87

− 0.29

− 0.78, 0.19

0.24

 Interaction (stroke × wave)

− 0.56

− 1.12, − 0.01

0.05

− 0.19

− 0.83, 0.45

0.56

Depression

− 0.04

− 0.10, 0.01

0.13

− 0.09

− 0.15, − 0.03

 < 0.01

 Interaction (wave × depression)

− 0.04

− 0.12, 0.03

0.26

− 0.01

− 0.08, 0.09

0.89