Figure 8

Scheme showing interface mutual information (\(\hat{I}_{AB}\)) optimization process for the HK-RR standard dataset. It starts from a within-species scrambled MSA concatenation and reaches an optimized concatenation. Different species are shown in different colors. Only physically coupled MSA position pairs (shown in purple) are taken into account and only within-species changes are made in each generation. This figure was created with Inkscape (https://inkscape.org/).