Figure 4 | Scientific Reports

Figure 4

From: Paclitaxel loading in cationic liposome vectors is enhanced by replacement of oleoyl with linoleoyl tails with distinct lipid shapes

Figure 4

Kinetic phase diagrams of PTX solubility in PTX-loaded CLs with DLin (di-linoleoyl, C18:2) lipid tails (DLinTAP/DLinPC/PTX mole ratio = 50/50–xPTX/xPTX). DIC microscopy (Fig. 3) was used to detect PTX crystallization at the indicated times after hydration. The blue color indicates absence of PTX crystals (i.e., PTX remained soluble in the membranes), while the red color indicates presence of PTX crystals. The boundary separating the blue region from the red region is termed the PTX membrane solubility boundary. As a reference to facilitate comparison, the black lines show the solubility boundary for PTX-loaded CLs with monounsaturated DO (di-oleoyl, 18:1) tails (DOTAP/DOPC/PTX molar ratio = 50/50-xPTX/xPTX)48. The change in tail structure strongly affects PTX membrane solubility. (a) Kinetic phase diagram for sonicated PTX-loaded DLinTAP/DLinPC CLs. (b) Kinetic phase diagram for unsonicated PTX-loaded DLinTAP/DLinPC CLs.

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