Figure 7

HGF/c-MET and NGF/TrkA signaling pathways influence esophageal epithelial regeneration in an Akt independent manner and in some cases modulate the expression of the anti-apoptotic protein, Birc3. Immunoblot analyses of p-Akt, Birc2, Birc3, and β-tubulin protein expression levels from neotissues treated with vehicle or inhibitors for 7 days of scaffold implantation. Vehicle and inhibitor-treated comparisons were made on the same immunoblots and with equal amounts of protein loaded per lane (N = 3–4 animals per group). Targeted bands were cropped from original full length immunoblots displayed in Supplementary Fig. S2.