Figure 4 | Scientific Reports

Figure 4

From: CRISPR/Cas9 generated knockout mice lacking phenylalanine hydroxylase protein as a novel preclinical model for human phenylketonuria

Figure 4

Analysis of Phe, Tyr and neurotransmitters in brains of Hom and Het Pah-KO mice at 6 months. Scatter plot charts show brain Phe, Tyr, serotonin, dopamine, L-DOPA, DOPAC, NE, 5-HIAA, and HVA. n = 6 Hom, 7 Het. Bars indicate group mean and the error bars indicate standard deviation (*p = 0.01, **p = 0.003—0.007, ***p = 0.0001, ****p < 0.0001).

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