Figure 6 | Scientific Reports

Figure 6

From: CRISPR/Cas9 generated knockout mice lacking phenylalanine hydroxylase protein as a novel preclinical model for human phenylketonuria

Figure 6

Cataract in Hom mice. (A) Note hypermature cataract characterized by collapsed and fragmented lens with the wrinkled capsule and formation of amorphous non-hyalinized core surrounded by protein globules in a Hom mouse as compared to the Het mouse. H&E stain. 1×. Higher magnification of lens showing disorganized, fragmented, and swollen lens fibers forming Morgagnian globules and hypereosinophilic condensed core in Hom mouse (B). H&E stain. 20×. (C) Summary of cataract score is shown in the scatter plot graph. n = 7 Hom, 7 Het. Bars indicate group median score and the error bars indicate range (***p = 0.0006).

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