Figure 8 | Scientific Reports

Figure 8

From: Transcriptional circuitry atlas of genetic diverse unstimulated murine and human macrophages define disparity in population-wide innate immunity

Figure 8

Transcriptome based comparative analysis identified expression disparities between the human population and five murine strains. (a) Heatmap of 19 inflammatory response genes expression in the different human populations (Asian, Black, Hispanic, and other races with regard to (w.r.t.) Caucasian individuals, and unstimulated macrophages of five murine strains (C57, BALB, NOD, PWK, and SPRET). (b) Heatmap of 32 type 1 IFN response genes expression in different human populations and unstimulated macrophages of five murine strains. (c) Heatmap of 96 pan basal homeostasis GRN TFs expression in different human populations and unstimulated macrophages of five murine strains. (d) Heatmap of 730 immune-related genes (form cluster A, B, C, d, and I of Fig. 2b) expression in different human population and unstimulated macrophages of five murine strains. Individual heatmap scale for human and murine samples.

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