Table 3 Model Parameters and the Range of Values Tested in Sensitivity Analyses.
Model input | Base-case | Range reference | References |
|---|---|---|---|
Cost inputs (2019 CNY) | |||
One-time hospitalization costs | |||
Ischemic stroke, (mRS 0–2) | 12,499.91 | 7,021.54–15,861.18 | |
Ischemic stroke, (mRS 3–6) | 18,700.45 | 9,711.31–24,627.33 | |
ICH, (mRS 0–2) | 14,086.15 | 7,515.65–17,613.39 | |
ICH, (mRS 0–2) | 18,700.45 | 9,711.31–24,627.33 | |
ECH | 9125.97 | 5,563.25–18,330.50 | |
MI | 21,276.20 | 8,292.31–37,291.96 | |
Annual posthospitalization costs | |||
Stroke, (mRS 0–2) | 8767.42 | 2189.32–10,945.34 | |
Stroke, (mRS 3–5) | 13,850.50 | 4104.98–18,060.64 | |
90-day | |||
Clopidogrel-aspirin price | 490.45 | ± 20% | |
Dipyridamole-aspirin price | 504 | ± 20% | |
Cost of genetic testing | 1,076.5 | ± 20% | |
Utility inputs | |||
Minor or no disability (mRS 0–2) | 0.75 | 0.70–0.90 | |
Moderate disability (mRS 3–4) | 0.39 | 0.10–0.5 | |
Severe disability (mRS 5) | 0.2 | 0.00–0.32 | |
Death (mRS 6) | 0 | 0.00–0.00 | |
Utility of major ECH | 0.8 | 0.79–0.84 | |
Utility of MI | 0.84 | 0.67–0.96 | |
Probabilities inputs | |||
Recurrent rate of stroke (per patient year) | 0.1219 | 0.1163–0.1276 | |
Among patients with recurrent stroke, proportion with: | |||
ICH | 0.075 | 0.075–0.146 | |
Death | 0.1933 | 0.1737–0.2128 | |
Relative risk of stroke recurrence per life-year | 1.017 | 1.013–1.022 | |
Age-specific nonstroke death rate | 0.0089–0.1654 | ||
Rate of major ECH | 0.0038 | 0.003–0.0048 | |
Mortality rate of major ECH | 0.06 | ± 20% | |
Rate of MI | 0.0085 | 0.006–0.0114 | |
Mortality rate of fatal MI | 0.15 | 0.103–0.246 | |
Discount rate inputs | |||
Costs | 0.03 | 0.03–0.08 | |
Outcomes | ± 20% | ||
