Figure 4

Increased nerve size is associated with pancreatic malignancy and patient survival. Pancreatic tissue sections from PC and normal adjacent tissue (NAT) were analyzed for changes in nerve size (measured by cross-sectional area). The nerve size was bigger in PC tissue than NAT (A). The median value of nerve area was taken as cut-off to define two groups (bigger nerve, nerve area bigger than median value and smaller nerve, nerve area smaller than median value) and used for the Kaplan–Meier analysis and the log-rank test. Bigger nerves in the tumor microenvironment was associated with worse patient survival (B). Survival analyses displayed a significantly shorter survival for patients with bigger nerve size than that of smaller nerve size. The results of comparative analyses are presented in Table 4A,B. PC pancreatic cancer.