Figure 1 | Scientific Reports

Figure 1

From: Identification of potential therapeutic antimicrobial peptides against Acinetobacter baumannii in a mouse model of pneumonia

Figure 1

Prophylactic intratracheal administration of TP4 and SMAP-29 reduced mortality associated with A. baumannii-induced pneumonia. (A) Mice were intratracheally infected with A. baumannii ATCC 17,978 at a dose of 5 × 108 CFU. A 10-μL aliquot of 2 × MIC of TP4 (16 μg/mL) and SMAP-29 (32 μg/mL) was intratracheally administered 30 min before bacterial infection and mouse survival detected daily (n = 10/group). (B) A. baumannii ATCC 17,978 (2–5 × 105 CFU) were mixed with 1 × and 2 × MIC of TP4 (8 and 16 μg/mL) or SMAP-29 (16 and 32 μg/mL) and incubated at 37 °C. The survival bacteria were detected by plating on agar plate.

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