Figure 2

Visualizations of biological processes within gene ontology categories for top lists of interesting genes indicated in the different approaches described in the results. The color scale indicates significance of the overrepresentation of genes and the gene ratio signifies the number of genes in each list relative to the number of genes in ontology categories. L designate the models examined using linear regression in the ‘limma’ package (‘L All’; n = 128 pairs); all pairs with metastatic cases (‘L Meta’, n = 100 pairs); and all pairs with metastatic cases sampled within three years prior to diagnosis (‘L Meta < 3 years’; n = 36 pairs), whereas S designate the spline regressions examined for all pairs and all pairs with metastatic cases using ‘limma’. For the significant curve groups identified, CG 123 and CG 321, the genes in the two significant curve groups were presented. Numbers in brackets signify the numbers of genes in each list with identified Entrez IDs that were included into the overrepresentation analyses. Graphical representation of ontologies were generated using the R package clusterProfiler²⁹.