Table 1 Frequency of KIR genotypes, linked gene groups, and genes in breast cancer patients and controls.

From: Coexistence of inhibitory and activating killer-cell immunoglobulin-like receptors to the same cognate HLA-C2 and Bw4 ligands confer breast cancer risk

KIR

Healthy controls

Breast cancer (BC)

Comparison

BC

Early

Advanced

BC vs Controls

Advanced vs Controls

n = 278

n = 162

n = 70

n = 44

p value

OR (95%CI)

p value

OR (95%CI)

KIR genotypes

%F

(N +)

%F

(N +)

%F

(N +)

%F

(N +)

AA genotypes

28.10

(78)

16.70

(27)

21.4

(15)

6.8

(3)

0.007

0.51 (0.31 to 0.84)

0.003

0.19 (0.06 to 0.62)

Bx genotypes

71.90

(200)

83.30

(135)

78.6

(55)

93.2

(41)

0.007

1.95 (1.19 to 3.18)

0.003

5.33 (1.6 to 17.72)

C4 linkage groups

33.50

(93)

35.80

(58)

35.7

(25)

27.3

(12)

    

T4 linkage groups

21.60

(60)

37.00

(60)

32.9

(23)

45.5

(20)

0.0005

2.14 (1.39 to 3.28)

0.001

3.03 (1.57 to 5.85)

KIR genes

Group-A haplotype-associated KIR genes

2DL1

97.8

(272)

96.9

(157)

97.1

(68)

95.5

(42)

    

2DL3

90.6

(252)

74.1

(120)

77.1

(54)

70.5

(31)

0.000003

0.29 (0.17 to 0.5)

0.0003

0.24 (0.11 to 0.52)

3DL1

95.7

(266)

90.1

(146)

91.4

(64)

88.6

(39)

0.02

0.41 (0.19 to 0.89

  

2DS4

96.0

(267)

91.4

(148)

91.4

(64)

90.9

(40)

0.04

0.44 (0.19 to 0.98)

  

Group-B haplotype-associated KIR genes

2DL2

59.7

(166)

69.8

(113)

70.0

(49)

72.7

(32)

0.035

1.56 (1.03 to 2.34)

  

2DL5

58.6

(163)

68.5

(111)

62.9

(44)

70.5

(31)

0.039

1.54 (1.02 to 2.3)

  

3DS1

34.2

(95)

46.3

(75)

41.4

(29)

59.1

(26)

0.01

1.66 (1.112 to 2.47)

0.002

2.88 (1.45 to 5.33)

2DS1

36.3

(101)

55.6

(90)

44.3

(31)

70.5

(31)

0.0001

2.19 (1.48 to 3.25)

0.0001

4.18 (2.09 to 8.35)

2DS2

54.7

(152)

52.5

(85)

58.6

(41)

43.2

(19)

    

2DS3

39.2

(109)

40.7

(66)

40.0

(28)

31.8

(14)

    

2DS5

25.5

(71)

43.2

(70)

38.6

(27)

52.3

(23)

0.0001

2.22 (1.47 to 3.35)

0.0005

3.19 (1.67 to 6.12)

Framework genes/pseudogenes

2DL4

100

(278)

100

(162)

100

(70)

100

(44)

    

3DL2

100

(278)

100

(162)

100

(70)

100

(44)

    

3DL3

100

(278)

100

(162)

100

(70)

100

(44)

    

2DP1

97.5

(271)

88.3

(143)

88.6

(62)

86.4

(38)

0.0003

0.19 (0.08 to 0.47)

0.0019

0.16 (0.05 to 0.51)

3DP1

100

(278)

100

(162)

100

(70)

100

(44)

    
  1. Carrier frequency (%F) of each genotype is expressed as a percentage and defined as the number of individual having the genotype (N +) divided by the number of studied (n) in the study group.
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