Table 3 Differentially expressed proteins and unique proteins commonly quantified in FFPE and OCT preserved samples (T2/T3 vs Ta/T1) and their relevance in cancer research.
Protein ID | Protein name | Gene name | FFPE (T2/T3 vs Ta/T1) | OCT (T2/T3 vs Ta/T1) | Cancer relevance | Ref | ||
|---|---|---|---|---|---|---|---|---|
Log2 fold change | P-value | Log2 fold change | P-value | |||||
P09382 | Galectin-1 | LGALS1 | 2.18 | 0.019 | 1.42 | 0.004 | Angiogenesis, invasion, cell–cell and cell–matrix interactions important for metastasis | |
P08758 | Annexin A5 | ANXA5 | 1.39 | 0.001 | 0.95 | 0.001 | Tumor progression, invasion, metastasis, drug resistance | |
P31930 | Cytochrome b-c1 complex subunit 1, mitochondrial | UQCRC1 | − 0.73 | 0.001 | − 1.02 | 0.017 | Highly expressed in breast and ovarian tumors | |
Q96I99 | Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial | SUCLG2 | − 0.77 | 0.034 | − 1.57 | 0.030 | Decreased expression in renal carcinoma | |
P38117 | Electron transfer flavoprotein subunit beta | ETFB | − 0.81 | 0.026 | − 1.43 | 0.017 | Biomarker of follicular carcinoma | |
P39687 | Acidic leucine-rich nuclear phosphoprotein 32 family member A | ANP32A | − 0.92 | 0.035 | − 1.03 | 0.017 | Promotes colorectal cancer proliferation | |
P51532 | Transcription activator BRG1 | SMARCA4 | − 1.37 | 0.010 | − 0.71 | 0.038 | Tumor suppressor | |
P49411 | Elongation factor Tu, mitochondrial | TUFM | − 1.20 | 0.039 | − 1.03 | 0.035 | Bad prognosis in colorectal and lung cancer | |
P54868 | Hydroxymethylglutaryl-CoA synthase, mitochondrial | HMGCS2 | Unique in Ta/T1 | Unique in Ta/T1 | Prognosis biomarker in several cancer tissues | |||
