Figure 1
From: Sex and Tamoxifen confound murine experimental studies in cardiovascular tissue engineering
Experimental Overview and Outcomes. Transverse (A) and cross-sectional (B) view of the TEVG. (C) IVC interposition TEVG at implantation (Left) and 2-week explantation (Right). (D) Timeline of tamoxifen treatment, implant, and explant. (E) Survival and TEVG patency of all experimental animals. (F) Surgical survival rate of mice on control diet, tamoxifen chow, and IP tamoxifen injection. (G) Occlusion rate of TEVGs at explant. (H) Weight of animals measured at tamoxifen start date, date of surgery, and explant at two weeks post-implantation. Scale bars = 500 µm (A and B), 2 mm (C). N = 15–20 for weight measurement and compared statisticallyusing t-tests. N = 15–20 for occlusion rate and compared using Fisher’s exact test. *p < 0.05, **p < 0.01, ***p < 0.001.
