Table 2 HRM pressure topography parameters of dry and wet swallows in the patients with normal HRM and of wet swallow in the patients with EGJOO and patients with achalasia.

From: Physiological and pathological roles of the accommodation response in lower esophageal sphincter relaxation during wet swallows

 

Normal HRM (n = 38)

EGJOO (n = 23)

Achalasia (n = 33)

Dry swallow

Wet swallow

Wet swallow

Wet swallow

Conventional HRM parameters

LES function, mmHg

BLESP

29.6 (25.6–36.4)

31.8 (23.8–36.4)

41.2 (33.8–50.6)b

33.2 (24.1–42.5)

4 s-IRP

17.9 (13.4–21.3)

10.9 (9.8–13.0)a

20.5 (18.3–23.6)b

22.1 (16.6–29.7)b

IBP at LESR

6.3 (3.2–11.3)

5.6 (4.8–8.3)

8.7 (5.2–12.7)b

n.a

IBP average max

13.9 (10.8–21.5)

12.3 (10.8–15.7)

17.1 (12.5–25.2)b

n.a

Esophageal body contractility

DCI, mm Hg·cm·s

1006 (533.8–1983.3)

1765.1 (904.2–2243.9)a

2049.6 (1366.2–2927.1)

n.a

DL, s

5.9 (4.8–6.7)

7.2 (6.5–7.6)a

6.1 (5.4–6.6)b

n.a

Original HRM parameters

Swallow-induced LES relaxation, mmHg

12.1 (8.0–16.1)

12.8 (8.6–19.1)

14.2 (11.4–19.7)

6.1(3.4–7.8)b,c

LES accommodation, mmHg

0.7 (− 1.1–2.8)

6.4 (3.1–11.1)a

0.6 (− 0.6–6.0)b

1.5 (− 3.1–6.9)b

Receptive LES relaxation, mmHg

n.a

2.6 (0.2–4.1)

 − 1.2 (− 3.0–0.9)b

n.a

LES accommodation measurement, mmHg

n.a

23.8 (18.0–28.6)

36.8 (29.5–44.3)b

32.6 (23.6–39.5)b

  1. EGJOO esophagogastric junction outflow obstruction; HRM high-resolution manometry; LES lower esophageal sphincter; IRP integrated relaxation pressure; IBP intrabolus pressure; LESR lower esophageal sphincter relaxation; DCI distal contractile integral; DL distal latency.
  2. Results are shown as the median (interquartile range).
  3. ap < 0.05 vs. Dry swallow in normal HRM.
  4. bp < 0.05 vs. Wet swallow in normal HRM.
  5. cp < 0.05 vs. EGJOO.
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