Table 4 Comparison of clinical manifestations between genetic skeletal disorder patients with and without CNS injury.

From: Identification of clinical and radiographic predictors of central nervous system injury in genetic skeletal disorders

Clinical manifestations

CNS injury n (%)

No CNS injury

n (%)

p*

OR

(95% CI)

Low back pain

40/71 (56.3)

72/201 (35.8)

0.003

2.3 (1.3–4.2)

ANPMD

14/71 (19.7)

16/201 (8.0)

0.007

2.8 (1.2–6.1)

Lower limb discrepancy

37/71 (52.1)

80/201 (39.8)

0.072

2.8 (1.2–6.6)

Ligament laxity

14/71 (19.7)

30/201 (14.9)

0.345

1.4 (0.6–3.0)

Joint dislocation

6/71 (8.5)

11/201 (5.5)

0.396

1.6 (0.5–4.9)

Joint deformity

56/71 (78.9)

149/201 (74.1)

0.425

1.3 (0.7–2.7)

Headache

23/71 (32.4)

69/201 (34.3)

0.767

0.9 (0.5–1.7)

  1. CNS central nervous system, ANPMD abnormal neuropsychomotor development, OR odds ratio, CI confidence interval.
  2. *X2 test or Fisher’s exact test.
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