Table 5 Comparison of radiological abnormalities between genetic skeletal disorder patients with and without CNS injury.

From: Identification of clinical and radiographic predictors of central nervous system injury in genetic skeletal disorders

Radiological abnormalities

CNS injury

n (%)

No CNS injury

n (%)

p*

OR

(95% CI)

Spine

41/71 (57.7)

78/201 (38.8)

0.006

2.1 (1.2–3.9)

Epiphyseal

23/71 (32.4)

40/201 (19.9)

0.032

1.3 (0.3–1.8)

Metaphyseal

34/71 (47.9)

124/201 (61.7)

0.043

0.6 (0.3–1.0)

Skull

14/71 (19.7)

22/201 (10.9)

0.061

2.0 (0.9–4.4)

Decreased bone density

21/71 (29.6)

82/201 (40.8)

0.125

0.6 (0.3–1.1)

Diaphyseal

13/71 (18.3)

28/201 (13.9)

0.440

1.4 (0.6–3.0)

Disorganized bone development

10/71 (14.1)

36/201 (17.9)

0.460

0.8 (0.3–1.7)

Increased bone density

2/71 (2.8)

9/201 (4.5)

0.734

0.6 (0.1–3.1)

  1. CNS central nervous system, OR odds ratio, CI confidence interval.
  2. *X2 test or Fisher’s exact test.
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