Figure 2 | Scientific Reports

Figure 2

From: Discovery of uncompetitive inhibitors of SapM that compromise intracellular survival of Mycobacterium tuberculosis

Figure 2

Dose–response curves and mode of inhibition for selected compounds. Compounds 1, 2, 13 and 14 were tested using the pNPP assay. (A) Common cis-benzylidenemalononitrile scaffold structure of the tyrphostin inhibitors and two examples compound 1 (C1) and 13 (C13). (B) Percentage of specific activity is calculated relative to the amount of p-nitrophenol released in the absence of inhibitor. Error bars represent ± SD of two independent experiments. (C) Mechanism of inhibition of SapM. Lineweaver–Burk plots for 1, 2, 13 and 14. Error bars represent ± SD of triplicates.

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