Figure 5 | Scientific Reports

Figure 5

From: A 3-month-delayed treatment with anatabine improves chronic outcomes in two different models of repetitive mild traumatic brain injury in hTau mice

Figure 5

Evaluation of disinhibition (time spent in open vs closed arms) in the 24r-mTBI and 5r-mTBI mice using the EPM. (A) There was no difference in time spent in open vs closed arms between the 24r-mTBI-vehicle (3.75 vs 81.46) and 24r-sham-vehicle (4.02 vs 82.12) and between the 24r-mTBI-vehicle (3.75 vs 81.46) and 24r-mTBI-anatabine (5.56 vs 72.56). (B) There was an increase in time spent in the open arms in 5r-mTBI-vehicle vs 5r-mTBI-sham mice (17.65 vs 10.97, p < 0.05). In the 5r-mTBI-anatabine mice, time spent in the open arms decreased compared to 5r-mTBI-vehicle (5.25 vs 17.65, p < 0.01). Statistical significance was analyzed using one-way ANOVA.

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