Figure 6 | Scientific Reports

Figure 6

From: A 3-month-delayed treatment with anatabine improves chronic outcomes in two different models of repetitive mild traumatic brain injury in hTau mice

Figure 6

Evaluation of the effect of anatabine on microglia. (A) Representative images of Iba1 in corpus callosum in the 5r-mTBI and 24r-mTBI mice. Arrow indicates immunoreactive microglia. (B) 24r-mTBI-vehicle mice had an increase in Iba1 signal compared to 24r-sham-vehicle (p < 0.05). (C) In 5r-mTBI-vehicle mice, no increased Iba1 was detected. Anatabine decreased Iba1 in 24r-mTBI mice (24r-mTBI-anatabine vs 24r-mTBI-vehicle p < 0.05) but not in 5r-mTBI. Inserts of 40× images of reactive microglia are included in pictures of each r-mTBI-vehicle group. Data analyzed using two-way ANOVA. Scale bars equal 20 µm.

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