Figure 3
Survival analysis according to B7-H6 expression and subgroups of combination between B7-H6 BCC or TILs-B7-H6 expression and immune parameters in breast cancer tissues. (a–b) Kaplan–Meier curves stratified on B7-H6 expression by cancer cells (B7-H6 BCC) for overall survival (OS) and disease free survival (DFS). (c–d) Kaplan–Meier curves stratified on B7-H6 expression by immune infiltrating cells (TILs-B7-H6) for OS and DFS. OS (e) and DFS (f) curves according to B7-H6 expression by tumor and immune cells together leading to three subgroups: subgroup 1: TILs-B7-H6Low/B7-H6 BCCLow, subgroup 2: TILs-B7-H6Low/B7-H6 BCCHigh and subgroup 3: TILs-B7-H6High/B7-H6 BCCHigh/Low. (g) OS curves according to B7-H6 BCC expression combined with PD-L1 BCC expression leading to three subgroups as follows: subgroup 1: B7-H6 BCCLow/PD-L1 BCCHigh/Low, subgroup 2: B7-H6 BCCHigh/PD-L1 BCCLow , subgroup 3: B7-H6 BCCHigh/PD-L1 BCCHigh. (h) OS curves according to B7-H6 BCC expression combined with TILs-PD-L1 status leading to three subgroups as follows: subgroup 1: B7-H6 BCCLow/TILs-PD-L1High/Low, subgroup 2: B7-H6 BCCHigh/TILs-PD-L1Low, subgroup 3: B7-H6 BCCHigh/TILs-PD-L1High. (i) OS curves according to B7-H6 BCC expression combined with NK-TILs status leading to three subgroups as follows: subgroup 1: B7-H6 BCCLow NK-TILsHigh/Low, subgroup 2: B7-H6 BCCHigh/ NK-TILsLow ,subgroup 3: B7-H6 BCCHigh/ NK-TILsHigh. (j) OS curves according to TILs-B7-H6 status combined with PD-L1 BCC expression leading to three subgroups as follows: subgroup 1: TILs-B7-H6Low/ PD-L1 BCCHigh/Low, subgroup 2: TILs-B7-H6High/ PD-L1 BCCLow, subgroup 3: TILs-B7-H6High/ PD-L1 BCCHigh. (k) OS curves according to TILs-B7-H6 status combined with TILs-PD-L1 status leading to three subgroups as follows: subgroup 1: TILs-B7-H6Low/ TILs-PD-L1High/Low, subgroup 2: TILs-B7-H6High/TILs-PD-L1Low, subgroup 3: TILs-B7-H6High/ TILs-PD-L1High. (l) OS curves according to TILs-B7-H6 status combined with NK-TILs status leading to three subgroups as follows: subgroup 1: TILs-B7-H6Low /NK-TILsLow, subgroup 2: TILs-B7-H6Low/NK-TILsHigh, subgroup 3: TILs-B7-H6High/ NK-TILsHigh/Low.
