Figure 5 | Scientific Reports

Figure 5

From: Establishing an immunocompromised porcine model of human cancer for novel therapy development with pancreatic adenocarcinoma and irreversible electroporation

Figure 5

Histopathology comparison of pre-clinical pancreatic cancer animal models. mouse Pan02, human PDX, and human Panc01 were compared. (A) Subcutaneous tumors in the mouse Pan02 model are densely cellular often with central areas of necrosis (asterisk). Individual cells are spindle-shaped and arranged in vague, irregular streams. (B) Subcutaneous tumors in the PDX mice are also highly cellular and also exhibit foci of necrosis (asterisk). At higher magnification, these cells are more polygonal and are often arranged to form irregular tubular structures with lumens containing inflammatory cellsmurin and debris (arrows). (C) Subcutaneous tumors in the porcine Panc01 model are also densely cellular and variably exhibit foci of necrosis. Individual cells are more polygonal in shape and rarely attempt to recapitulate glandular structures (arrows).

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