Figure 3 | Scientific Reports

Figure 3

From: Characterization of clostridium botulinum neurotoxin serotype A (BoNT/A) and fibroblast growth factor receptor interactions using novel receptor dimerization assay

Figure 3

rHC/A induces FGFR3c dimerization. Native ligand FGF9 (black) (EC50 = 18 nM [95% CI; 13, 24]) and BoNT/A binding domain (rHC/A) (green) (EC50 = 27 nM [95% CI; 18, 41]), but not FGF10 (red), dimerize fluorescently tagged FGFR3c in transfected PC-12 cells. Points represent the average normalized brightness values ± SD from greater than 30 cells collected on 4 independent days.

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