Figure 1
From: Olig2 regulates p53-mediated apoptosis, migration and invasion of melanoma cells
Olig2 was upregulated in melanoma. (a) The levels of Olig2 was determined by analysis of GSE7553 public dataset containing the gene expression of normal melanocyte (n = 4), primary melanoma (n = 14) and metastatic melanoma (n = 40). The data was analyzed using Wilcoxon signed-rank tests (ns: not significant, *p < 0.05; **p < 0.01 versus Normal) (b) IHC analysis of Olig2 in normal skin (n = 8) and malignant melanoma skin (n = 40) tissue sample was performed and (c) the representative graph was shown. p values were analyzed using unpaired Student’s t-test (*p < 0.05; **p < 0.01) (d) Normal human melanocyte (NHEM) and four human metastatic melanoma cells were lysed with lysis buffer. Olig2 protein expression was detected by western blot analysis with Olig2 (H-10) antibody.
