Figure 9
From: Olig2 regulates p53-mediated apoptosis, migration and invasion of melanoma cells
Olig2 regulates apoptosis, migration and invasion of melanoma cells. Both PI3K and MAPK pathways are involved in the regulation of Olig2 in melanoma cells. Inhibition of Olig2 induces p53 apoptosis pathway, then decreases viability of melanoma cells. Olig2 regulates EMT transcription factors such as snail and slug, and subsequently E-cadherin, N-cadherin and MMPs. Down regulation of Olig2 suppressed migration and invasion of melanoma cells.
