Figure 4

Efficacy of treatment of the osteosarcoma PDOX mouse model on tumor histopathology. Hematoxylin & eosin staining. (A) Group 1 treated with PBS; (B) Group 2 treated with DOX; (C) Group 3 treated with EVE-alone; (D) Group 4 treated with PAZ-alone; (E) Group 5 treated with the combination of EVE and PAZ. Yellow arrows indicate necrotic areas within the tumor. Scale bars are 100 μm.