Table 2 Fourfold table of the validation data.

From: First approach to distinguish between cardiac and arteriosclerotic emboli of individual stroke patients applying the histological THROMBEX-classification rule

Rater I (N = 81)/Rater II (N = 82)

Histological classification

CARDIO

ARTERIO

Stroke etiology

Cardioembolic (E1)

39/43

15/12

Arterioembolic (E2)

8/7

19/20

Agreement concerning E1

[%, (95% CI)], Rater I: N = 54; Rater II: N = 55

72,2 (58,4–83,5) /

78,2 (65,0–88,2)

Agreement concerning E2

[%, (95% CI)], both raters: N = 27

70,4 (49,8–86,3) /

74,1 (53,7–88,9)

Agreement concerning E1 + E2

[%, (95% CI)], Rater I: N = 81; Rater II: N = 82

71,6 (60,5–81,1) /

76,8 (66,2–85,4)

  1. Stroke etiology was independently determined by three stroke experts based on complete anamnestic information and diagnostic results concerning cause analysis of stroke. Histological classification was performed by two independent raters that were blinded for the defined etiology of the thrombotic emboli. Values for both raters are indicated before (rater I) and after (rater II) the slash. CI = confidence interval.
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