Figure 3

TNF down-regulates inhibitors of mineralization (a) ANKH, (b) ENPP1 and increases expression of hypertrophy markers, (c) RUNX2, (d) COL10A1 in TNAP transduced bNPs (n = 3). Data are mean ± S.E.M. of 3 experiments. Significance represents *p < 0.05 or **p < 0.005 compared to naïve cells. Data analyzed using One-way ANOVA.