Figure 8[replace with the revised figure]
From: Functional NMDA receptors are expressed by human pulmonary artery smooth muscle cells
![Figure 8[replace with the revised figure]](http://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41598-021-87667-0/MediaObjects/41598_2021_87667_Fig8_HTML.png)
NMDA receptors regulate endothelin-1 (ET-1)-induced pulmonary vasoconstriction in murine precision-cut lung slices. ET-1 induced pulmonary vasoconstriction under a normoxic (21% O2) condition in a dose-dependent manner (A). Pretreatment with 10 µM MK801 or 50 µM AP5 significantly attenuated ET-1-induced maximal vasoconstriction (Emax) (B), the sensitivity of the pulmonary vessels to ET-1 measured by Log EC50 of the dose–response curve (C), and the area under the curve (AUC) (D). *p < 0.05, ***p < 0.0001, n = 3.
