Figure 6

Comparison of posterior parameter distributions between the no drug treatment and drug treatments. Asterisks indicate distributions that differ significantly from the no drug treatment after Bonferroni correction for multiple testing. Non significant (ns) corresponds to \(p > 0.05\), a single asterisk corresponds to p \(\le\) 0.05, two asterisks correspond to p \(\le\) 0.01, three correspond to p \(\le\) 0.001, and four correspond to p \(\le\) 0.0001 from a K-S test. Parameters are estimated by fitting the model described by the equations in Table 1 and illustrated in Fig. 2A. Parameters correspond to those labeled in each reaction. (A) Translation, which occurs in step 3 of the model. (B) Compartmentalization, a part of step 4. (C) Circularization, step 5. (D, E) Replication of positive and negative sense RNA, step 6. (F) Packaging, step 7. (G) The maximum number of compartments possible, considered in step 6. (H) The maximum number of replication cycles permitted by cellular resources, a limiting factor in step 4. (I) Consumption of the protein product 3A, step 4. (J) The probability for a newly synthesized genome to stay in the replication complex, step 8.