Table 2 Effect of MET treatment on ZIKV or DENV infected AG129 mice.
From: The antiviral effect of metformin on zika and dengue virus infection
Treatment groups | # events (n) | Median survival (days) | Average survival rate (days) | Are the survival curves sig different? | Are the Average survival rate sig different? | Remarks |
|---|---|---|---|---|---|---|
ZIKV | 16 (9 ♂, 7 ♀) | 16 | 14.63 ± 1.821 | NO | NO | Slight exacerbation of clinical signs of ZIKV (increased paralysis of the back and extremities) in MET-treated female mice |
ZIKV + MET | 21 (10 ♂, 11 ♀) | 14 | 14.00 ± 1.975 | |||
DENV | 12 (8 ♂, 3 ♀) | 13 | 12.92 ± 2.10 | YES Log-rank (Mantel-Cox) test * p = 0.0339 YES Gehan-Breslow-Wilcoxon test * p = 0.0358 | YES ANOVA-LSD *p = 0.0197 | Mice treated with MET showed mild signs of DENV and a higher median and median survival rate than untreated mice |
DENV + MET | 12 (9 ♂, 4 ♀) | 15 | 14.83 ± 1.69 |
