Table 7 “Disease Perturbations from GEO down/up” category of Enrichr for 53 genes (based on gene expression) and 200 genes (based on m6A) selected by applying KTD-based unsupervised FE to integration of gene expression and m6A profiles. Nine hypoxia experiments with adjusted P-values less than 0.05 are listed.
Term | Overlap | P-value | Adjusted P-value |
|---|---|---|---|
Gene expression | |||
Disease perturbations from GEO down | |||
Hypoxia C0242184 human GSE4630 sample 250 | 15/349 | \(1.08\times 10^{-14}\) | \(7.85\times 10^{-14}\) |
Hypoxia C0242184 mouse GSE3195 sample 70 | 12/328 | \(4.53\times 10^{-11}\) | \(2.03\times 10^{-10}\) |
Hypoxia C0242184 human GSE4483 sample 440 | 10/275 | \(2.38\times 10^{-9}\) | \(8.67\times 10^{-9}\) |
Disease perturbations from GEO up | |||
Hypoxia C0242184 human GSE4483 sample 440 | 27/325 | \(1.10\times 10^{-34}\) | \(1.15\times 10^{-32}\) |
Hypoxia C0242184 mouse GSE3195 sample 70 | 10/272 | \(2.14\times 10^{-9}\) | \(5.79\times 10^{-9}\) |
Hypoxia C0242184 human GSE4630 sample 250 | 9/251 | \(1.83\times 10^{-8}\) | \(4.51\times 10^{-8}\) |
m6A | |||
Disease perturbations from GEO up | |||
Hypoxia C0242184 human GSE4483 sample 440 | 30/325 | \(1.91\times 10^{-20}\) | \(1.60\times 10^{-17}\) |
Hypoxia C0242184 mouse GSE3195 sample 70 | 21/272 | \(4.63\times 10^{-13}\) | \(1.94\times 10^{-10}\) |
Hypoxia C0242184 human GSE4630 sample 250 | 17/251 | \(6.56\times 10^{-10}\) | \(4.24\times 10^{-8}\) |
