Figure 4
Micro-CT based evaluation of bone parameters in the collagen group (blue) and the collagen + BMP-2 group (red) using different VOIS: defect center (DC; a–c), defect periphery (DP; d–f), cortical fragment center (FC; g–i), cortical fragment periphery (FP; j–l). (a, d, g, j) Bone formation rate (solid line) and bone resorption rate (dashed line) given in percent per day. (b, e, h, k) Bone volume (BV) normalized to TV (DC for DC and DP, FC for FC + FP). (c, f, i, l) Degree of bone mineralization given as ratio of bone volume with a density ≥ 645 mg HA/cm3 to the total osseous volume (threshold ≥ 395 mg HA/cm3). n = 7/10; (a, d, g, j) *indicates p < 0.05 between consecutive weeks; #indicates p < 0.05 between groups. (b, c, e, f, h, I, k, l) *indicates p < 0.05 between groups; #indicates p < 0.05 between consecutive weeks.
