Figure 6
From: Potent sialic acid inhibitors that target influenza A virus hemagglutinin
Time-of-addition assay. (a) Schematic representation of the antiviral activity of NSC47715 compound in different entry stages. (b) MDCK cells were infected with H1N1 (A/WSN/1933) and treated with NSC47715 compound at the concentration of EC90(µM) at the indicated time according to the different strategy presented above. The values were presented as mean ± standard error of three independent experiments and were normalized to the values of DMSO solvent control. ***(p < 0.0001) shows there is a statistically different between NSC47715 and DMSO solvent control in the attachment stage.
