Figure 3
Additional verification of the IMK model in comparison with the experimental data. (A) The surviving fraction of HT1080 cells was treated with the 100 μM 4-MU and the ROS inhibitor (1% DMSO) or NO inhibitor (40 μM c-PTIO). We estimated surviving fraction based on the IMK model and the model parameters listed in Table 1. (B) The surviving fraction as a function of the 4-MU concentration with a constant 2 Gy irradiation. Red solid line represents the surviving fraction estimated by the IMK model, red circle the experimental cell survival treated with the 100 μM 4-MU, and green dot line the cell survival estimated by the IMK model considering only DNA-TEs.
