Table 1 Model parameters of the IMK model.

From: 4-Methylumbelliferone administration enhances radiosensitivity of human fibrosarcoma by intercellular communication

Model parameters

Unit

Values

Mean

s.d

Pharmacological effects

Smin

–

0.0003

0.0002

Smax

–

1.000

–

ED50

μM

92.07

1.797

rd

–

1.637

0.012

Microdosimetric quantity

yD

keV/mm

4.683

0.050

g

Gy

0.954

0.011

DNA-targeted effects

α0

Gy−1

0.053

0.028

β0

Gy−2

0.069

0.004

a + c

h−1

2.215

0.007

Intercellular communication

αb

Gy−1

0.010

0.006

βb

Gy−2

0.032

0.018

δmin

–

0.760

0.016

δmax

–

8.175

 < 0.001

rδ

–

8.816

0.011

  1. These model parameters determined by fitting Eqs. (1)–(6) to the experimental survival (Fig. 2) by means of maximum likelihood method. The values were presented mean ± fitting error (s.d.).
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