Figure 2 | Scientific Reports

Figure 2

From: Differences in host immune populations between rhesus macaques and cynomolgus macaque subspecies in relation to susceptibility to Mycobacterium tuberculosis infection

Figure 2

Cell populations in PBMCs determined by flow cytometric analysis in rhesus and cynomolgus macaques. (A) CD3+ lymphocytes, (B) CD4 + T-cells, (C) CD8 + T-cells, (D) CD4 + CD8 + DP T-cells, (E) CD4:CD8 ratio, (F) proportions of CD4+, CD8+ and CD4+CD8+ lymphocytes, (G) NK T-cells, (H) CD11c+ B-cells, (I) CD159+ NK cells, (J) CD16 + NK cells, (K) CD56 + NK cells, (L) CD16 + CD56 + DP NK cells, (M) proportions of cytotoxic (CD16 + CD56-), intermediate (CD16+ CD56+) and immunomodulatory (CD16− CD56+) NK cells, (N) Monocytes, (O) CD14 + monocytes, (P) CD16 + monocytes, (Q) CD14 + CD16 + monocytes, (R) proportions of classical (CD14+ CD16−), intermediate (CD14+ CD16+) and non-classical (CD14− CD16+) monocytes, (S) mDCs. Each data point represents an individual animal. Bars represent mean values in graphs F, M and R. Group numbers varied between comparisons, as previous immunophenotyping data for ICM and CCM was used to bolster comparisons: Rhesus (Blue) n = 20 and MCM (Red) n = 19. For lymphocyte comparisons ICM (Green) n = 18 and CCM (Purple) n = 22. For comparisons monocytes and NK cells, ICM (Green) n = 8 and CCM (Purple) n = 15. Kruskall-Wallis tests with Dunn’s multiple comparisons were applied, *p = 0.05, **p < 0.01 and ***p < 0.001.

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