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Figure 2

From: Chronic intermittent ethanol promotes ventral subiculum hyperexcitability via increases in extrinsic basolateral amygdala input and local network activity

Figure 2

CIE shifts the excitatory/inhibitory balance in the BLA-vSub pathway toward a hyperexcitable state (A) Monosynaptic oEPSC amplitudes (left graph) and polysynaptic oEPSC areas (right graph) are increased in vSub neurons of CIE rats. (B) Representative monosynaptic (upper traces) and polysynaptic (lower traces) traces from a vSub neuron of Air (left column) and CIE (right column) rats. (C) Representative traces of oIPSCs (upper traces) and oEPSCs (lower traces) recorded from the same neuron. (D) Polysynaptic oIPSC areas are increased in vSub neurons of CIE rats (right panel) but this increase is smaller than the relative increase in oEPSC areas, resulting in an overall greater E/I ratio (right panel). In representative traces, individual inputs are shown by thin lines while the average response amplitude is illustrated by a thicker overlaid line. Blue bars above figures illustrate onset and duration of optical stimulation. *p < 0.05, ** p < 0.01 and ***p < 0.001 and errors are reported as ± SEM.

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