Figure 4 | Scientific Reports

Figure 4

From: Chronic intermittent ethanol promotes ventral subiculum hyperexcitability via increases in extrinsic basolateral amygdala input and local network activity

Figure 4

AMPA-mediated oEPSCs and AMPA/NMDA ratios are increased in vSub neurons of CIE rats. (A) Evoked monosynaptic amplitudes (left graph) and polysynaptic areas (right graph) of AMPA-mediated oEPSCs of vSub neurons in the presence of PTX are increased in vSub neurons of CIE rats. (B) Representative traces of monosynaptic (upper traces) and polysynaptic (lower traces) AMPA-mediated oEPSCs shown in (A) of Air (left column) and CIE (right column) rats. (C) oEPSCs recorded in the presence of PTX at − 80 mV (lower traces) to isolate AMPA-mediated EPSC amplitude and at + 40 mV (upper traces) to establish the NMDA-mediated amplitude within the same vSub neuron. (D) CIE rats have an increased AMPA/NMDA ratio (right graph) in CIE rats that cannot be explained by a change in AMPA tau (left graph). In representative traces, individual inputs are shown by thin lines while the average response amplitude is illustrated by a thicker overlaid line. Blue bars above figures illustrate onset and duration of optical stimulation. *p < 0.05 and ** p < 0.01 and errors are reported as ± SEM.

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